A new resin-bound universal isonitrile for the Ugi 4CC reaction: preparation and applications to the synthesis of 2,5-diketopiperazines and 1,4-benzodiazepine-2,5-diones.
Org Lett
; 4(7): 1167-70, 2002 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-11922809
ABSTRACT
[reaction see text] The preparation and synthetic applications of a novel resin-bound isonitrile are described. The resin is an example of a novel convertible isonitrile that can be utilized in the Ugi multicomponent reaction. Base-activation of the resin-bound Ugi product results in cleavage via formation of a N-acyloxazolidone that is then trapped as a carboxylic acid ester. This resin and the methodology described are suitable for synthesizing diversity libraries of 2,5-diketopiperazines and 1,4-benzodiazepine-2,5-diones.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Benzodiazepinas
/
Nitrilas
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article