Complement modulating activity of Rwandan medicinal plants.
Phytomedicine
; 9(1): 56-61, 2002 Jan.
Article
em En
| MEDLINE
| ID: mdl-11924765
ABSTRACT
Forty-two ethanolic extracts of thirty-six Rwandan medicinal plants were investigated for their influence on complement-mediated hemolysis. The plants were selected on the base of their ethnomedicinal use in infections and autoimmune diseases. Eight plant extracts showed an inhibitory activity against the classical pathway of the complement system and ten plant extracts against the alternative pathway. Three plant extracts exhibited an interesting activity against both pathways, i.e. Aspilia pluriseta, Coleus kilimandschari, and Macaranga kilimandscharica (leaves and stem). Further study indicated that the complement inhibitory activity was not caused by chelation of bivalent cations or by direct action on the target erythrocytes.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Medicinas Tradicionais Africanas
/
Ativação do Complemento
/
Eritrócitos
/
Hemólise
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Fitoterapia
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article