Interleukin-2 in the pathogenesis of perinatal white matter damage.
Neurology
; 58(7): 1125-8, 2002 Apr 09.
Article
em En
| MEDLINE
| ID: mdl-11940709
ABSTRACT
Proinflammatory cytokines were reported to be implicated in the pathogenesis of perinatal white matter lesions. The authors document for the first time the in situ detection of interleukin-2 and interleukin-2 receptor (IL-2R) in these human white matter lesions. These results suggest that interleukin-2, reported to be toxic to oligodendrocytes and myelin, could play a role in the molecular cascade leading to white matter damage in periventricular leukomalacia.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Recém-Nascido
/
Recém-Nascido Prematuro
/
Interleucina-2
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article