Characterization of stable conformational variants of erythrocyte carbonic anhydrases.
Biochimie
; 61(10): 1161-8, 1979.
Article
em En
| MEDLINE
| ID: mdl-119551
ABSTRACT
Limiting viscosity numbers of bovine and ovine erythrocytes carbonic anhydrase variants were calculated by the objective method of comparing viscosimetric data obtained from low-activity-human erythrocyte carbonic anhydrase and its natural variant. Shifts of mobilities and isoelectric points are shown for all species variants, but variations of limiting viscosity numbers were only detected for human and bovine variants. Results of the study are consistent with the observation that variants arise by deamidation of erythrocyte carbonic anhydrases, and that deamidation is responsible for changes in structure and hydration (i. e. "conformational" modifications). Thus, all the variants so far investigated are stable conformational variants or erythrocyte carbonic anhydrases.
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Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Anidrases Carbônicas
/
Eritrócitos
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article