Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend.
J Control Release
; 81(1-2): 57-64, 2002 May 17.
Article
em En
| MEDLINE
| ID: mdl-11992678
ABSTRACT
Electrospun fiber mats are explored as drug delivery vehicles using tetracycline hydrochloride as a model drug. The mats were made either from poly(lactic acid) (PLA), poly(ethylene-co-vinyl acetate) (PEVA), or from a 5050 blend of the two. The fibers were electrospun from chloroform solutions containing a small amount of methanol to solubilize the drug. The release of the tetracycline hydrochloride from these new drug delivery systems was followed by UV-VIS spectroscopy. Release profiles from the electrospun mats were compared to a commercially available drug delivery system, Actisite (Alza Corporation, Palo Alto, CA), as well as to cast films of the various formulations.
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Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Polivinil
/
Tetraciclina
/
Sistemas de Liberação de Medicamentos
/
Ácido Láctico
/
Antibacterianos
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article