Comparison of the effect of intrathecal endomorphin-1 and endomorphin-2 on spinal cord excitability in rats.
Neurosci Lett
; 324(3): 197-200, 2002 May 24.
Article
em En
| MEDLINE
| ID: mdl-12009522
ABSTRACT
We examined and compared the effects of intrathecal (i.t.) endomorphin-1 and endomorphin-2 on the nociceptive flexor reflex in decerebrate, spinalized, unanesthetized rats. I.t. endomorphin-1 and -2 induced a dose-dependent depression of the flexor reflex with an initial brief facilitatory effect. The magnitude of reflex facilitation and depression was similar between endomorphin-1 and -2, but the duration of depression was significantly longer for endomorphin-1 than endomorphin-2. The results suggested that the spinal antinociceptive effects of endomorphin-1 and -2 are similar, with endomorphin-1 being more resistant to enzymatic degradation.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Dor
/
Reflexo
/
Medula Espinal
/
Nociceptores
/
Analgésicos Opioides
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article