Lipoprotein(a), apolipoprotein E genotype, and risk of Alzheimer's disease.
J Neurol Neurosurg Psychiatry
; 72(6): 732-6, 2002 Jun.
Article
em En
| MEDLINE
| ID: mdl-12023414
ABSTRACT
OBJECTIVES:
To explore the possible role of serum lipoprotein(a) (Lp(a)), apolipoprotein E polymorphism, and total cholesterol (TC) serum concentrations in Alzheimer's disease (AD).METHODS:
Lp(a) serum concentrations, apolipoprotein E genotypes, and TC serum concentrations were determined in 61 patients with a diagnosis of probable AD and in 63 healthy unrelated age matched controls. Genomic DNA was obtained and amplified by polymerase chain reaction and apolipoprotein E genotypes were defined following a previously described procedure.RESULTS:
Lp(a) serum concentrations were significantly associated in a non-linear relation with an increased risk for AD, independently of apolipoprotein E genotypes and sex and dependent on age (truth association) and TC serum concentrations (spurious association). The effect of age adjusted for TC on the odds of having AD increased non-linearly with increasing Lp(a) serum concentrations, with a plateau between 70 and 355 mg/l (odds ratio 11.33). For Lp(a) serum concentrations > or = 360 mg/l, the effect of age (> or = 72 years) was associated with a reduction in odds of having AD (odds ratio 0.15).CONCLUSION:
It is suggested that increased Lp(a) serum concentrations, by increasing the risk for cerebrovascular disease, may have a role in determining clinical AD.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
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Lipoproteína(a)
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Predisposição Genética para Doença
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Doença de Alzheimer
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article