[PAX-6 gene promoter polymorphism and other factors involved in brain atrophy in alcohol dependent patients]. / Polimorfizm genu promotora PAX-6 i inne czynniki zwiazane z atrofia mózgowia u osób uzaleznionych od alkoholu.

ABSTRACT

PAX-6 gene promoter polymorphism, alcohol dependence history and CT were determined in the group of 68 alcoholics. We found negative correlation between numbers of PAX-6 gene promoter B (AC)m (AG)n repeats and atrophy of the brain and the cerebellum. Occurrence of these lesions was correlated with a decrease of alcohol tolerance, withdrawal symptoms--especially delirium tremens.