Alcohol differentially affects c-Fos expression in the supraoptic nucleus of long-sleep and short-sleep mice.
Brain Res
; 935(1-2): 114-7, 2002 May 10.
Article
em En
| MEDLINE
| ID: mdl-12062480
ABSTRACT
Ethanol administration in long-sleep (LS) and short-sleep (SS) mice results in a large number of Fos-IR neurons in the supraoptic nucleus (SON) in LS, and almost no Fos-IR neurons in the same nucleus in SS mice. In contrast, isotonic saline, hypertonic saline, with or without ethanol, resulted in a similar pattern of Fos-IR in both strains. These data indicate a differential effect of ethanol on c-Fos signaling specifically in the SON. Since the LS and SS mice were specifically selected for differential sensitivity to the sedative/hypnotic effects of ethanol, this differential in c-Fos activity may be causally implicated in their differential sensitivity to ethanol.
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Base de dados:
MEDLINE
Assunto principal:
Sono
/
Núcleo Supraóptico
/
Depressores do Sistema Nervoso Central
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Proteínas Proto-Oncogênicas c-fos
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Transtornos do Sistema Nervoso Induzidos por Álcool
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Etanol
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Tolerância a Medicamentos
/
Neurônios
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article