Hydrops fetalis-associated congenital dyserythropoietic anemia treated with intrauterine transfusions and bone marrow transplantation.
Blood
; 100(1): 356-8, 2002 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-12070051
ABSTRACT
Hydrops fetalis is rarely caused by congenital dyserythropoietic anemia (CDA). We report a patient with hydrops fetalis as a result of severe anemia. This patient needed intrauterine transfusions from 21 weeks of gestation until birth. The hematologic study showed an atypical CDA (hydrops fetalis-associated CDA) characterized by features resembling CDA type II, but negative acidified serum lysis test (HEMPAS negative). The patient was regularly transfused for a year, after which an allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling was successfully carried out. His actual hemoglobin is 127 g/L, and he has not received transfusions for more than a year. In conclusion, intrauterine transfusions and BMT could cure an otherwise lethal atypical CDA.
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Base de dados:
MEDLINE
Assunto principal:
Transfusão de Sangue Intrauterina
/
Hidropisia Fetal
/
Transplante de Medula Óssea
/
Anemia Diseritropoética Congênita
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article