The FAS-670 polymorphism influences susceptibility to multiple sclerosis.
J Neuroimmunol
; 128(1-2): 95-100, 2002 Jul.
Article
em En
| MEDLINE
| ID: mdl-12098516
ABSTRACT
Several studies have reported a defective Fas function in patients with multiple sclerosis (MS). We were interested whether this could result from a genetically altered Fas regulation. We examined the FAS-670 polymorphism in 382 patients with MS and 206 controls, and found that the carriership of allele FAS-670*G was significantly less frequent in patients than in controls. We found no association between the carriership of FAS-670*G and clinical features. For a subgroup of patients, longitudinal MRI data were available. We observed similar brain and lesion volumes in carriers and noncarriers of FAS-670*G. These data suggest that FAS-670*G decreases the risk of developing MS, but does not affect the course of disease.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Glicoproteínas de Membrana
/
Receptor fas
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Predisposição Genética para Doença
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Esclerose Múltipla
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article