New enamine derivatives of lapachol and biological activity.
An Acad Bras Cienc
; 74(2): 211-21, 2002 Jun.
Article
em En
| MEDLINE
| ID: mdl-12098751
ABSTRACT
A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells.
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Base de dados:
MEDLINE
Assunto principal:
Naftoquinonas
/
Aminas
/
Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article