[Topical 5-fluorouracil for treatment of vaginal intraepithelial neoplasms]. / 5-fluorouracilo tópico en el tratamiento de la neoplasia intraepitelial vaginal.
Ginecol Obstet Mex
; 70: 244-7, 2002 May.
Article
em Es
| MEDLINE
| ID: mdl-12148464
ABSTRACT
OBJECTIVE:
Our purpose was to determine the effectiveness of 5-fluorouracil (5-FU) in the treatment of vaginal intraepithelial neoplasia (VAIN). MATERIALS ANDMETHODS:
The study was performed in 30 patients with a mean age of 54 years and previous diagnoses from reviewed records and histopathology slides selected from a group of 65 patients with VAIN from 1980 to 1998. Patients received intravaginal treatment with 5-FU, 1.5 g once weekly for 10 weeks and all patients were followed up for at least 2-years. Papanicolaou smear and colposcopy were performed, as was biopsy when indicated.RESULTS:
Twenty eight (93%) patients with VAIN had prior or concurrent anogenital squamous neoplasia, including 5 with invasive cervical carcinoma and 23 with cervical intraepithelial neoplasia. In 23 of 30 treated patients (77%), VAIN went into remission after a single treatment; in 3, (10%), it went into remission after two treatment; 3 (10%) had recurrent VAIN 3; and in 1 (3%) it progressed to invasive vaginal cancer. The treatment was well tolerated.CONCLUSIONS:
The 5-FU is an option choice for VAIN treatment. It is effective, with minimal slide effects. Its use should be confined to treating extensive or multifocal high-grade VAIN.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Vaginais
/
Displasia do Colo do Útero
/
Fluoruracila
/
Antimetabólitos Antineoplásicos
Idioma:
Es
Ano de publicação:
2002
Tipo de documento:
Article