Parallel solution- and solid-phase synthesis of spirohydantoin derivatives as neurokinin-1 receptor ligands.
Bioorg Med Chem Lett
; 12(18): 2519-22, 2002 Sep 16.
Article
em En
| MEDLINE
| ID: mdl-12182851
ABSTRACT
The combination of the 3,5-bis(trifluoromethyl)phenyl group with a spirohydantoin motive as a central scaffold was the basis for the design of a combinatorial library targeted towards the neurokinin-1 receptor. A solution- and solid-phase procedure is described and binding affinities of representative compounds presented.
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Base de dados:
MEDLINE
Assunto principal:
Compostos de Espiro
/
Receptores da Neurocinina-1
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article