Synthesis and cytotoxic activity of pyridazino[1',6':1,2]pyrido[3,4-b]indol-5-inium derivatives as anti-cancer agents.

Fontana, Alberto; Benito, Enrique J; Martín, M Justina; Sánchez, Nuria; Alajarín, Ramón; Vaquero, J José; Alvarez-Builla, Julio; Lambel-Giraudet, Stéphanie; Leonce, Stéphane; Pierré, Alain; Caignard, Daniel

Fontana, Alberto; Benito, Enrique J; Martín, M Justina; Sánchez, Nuria; Alajarín, Ramón; Vaquero, J José; Alvarez-Builla, Julio; Lambel-Giraudet, Stéphanie; Leonce, Stéphane; Pierré, Alain; Caignard, Daniel.

Afiliação

Fontana A; Departamento de Qui;mica Orgánica, Universidad de Alcalá, 28871-Alcalá de Henares, Madrid, Spain.

Bioorg Med Chem Lett ; 12(18): 2611-4, 2002 Sep 16.

Article em En | MEDLINE | ID: mdl-12182872

ABSTRACT

ABSTRACT

Several new pyridazino[1',6'1,2]pyrido[3,4-b]indol-5-inium derivatives were synthesised from beta-carboline derivatives and their cytotoxic activity and effect on the cell cycle were evaluated against L1210 cancer cells.

Assuntos

Antineoplásicos/síntese química; Antineoplásicos/farmacologia; Indóis/síntese química; Indóis/farmacologia; Animais; Antineoplásicos/química; Ensaios de Seleção de Medicamentos Antitumorais; Indóis/química; Leucemia L1210/patologia; Células Tumorais Cultivadas

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