Molecular defects in coagulation Factor VIII and their impact on Factor VIII function.
Vox Sang
; 83(2): 89-96, 2002 Aug.
Article
em En
| MEDLINE
| ID: mdl-12201837
ABSTRACT
Molecular defects in Factor VIII (FVIII), such as haemophilia A-related mutations or denaturative conformational changes, may affect the stability of FVIII as well as its interactions with physiological activators, von Willebrand Factor, phospholipid, or conformationally sensitive antibodies. We summarize the contemporary assays which allow identification of impaired functional interactions of FVIII that cause a reduction or loss of its cofactor activity and/or increased immunogenicity. These assays can potentially be used for detection of molecular defects in FVIII and elucidation of the function impaired by these defects.
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Base de dados:
MEDLINE
Assunto principal:
Fator VIII
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article