Thymic lesions and myasthenia gravis. Diagnosis based on mediastinal imaging and pathological findings.
Acta Radiol
; 43(4): 380-4, 2002 Jul.
Article
em En
| MEDLINE
| ID: mdl-12225479
ABSTRACT
PURPOSE:
To achieve a better understanding of the role of CT and MR imaging in the study of the mediastinum in patients with myasthenia gravis (MG). MATERIAL ANDMETHODS:
Mediastinal CT and MR findings were correlated with the histopathological results in 104 thymectomized MG patients.RESULTS:
CT was performed in 104 patients; in 11 of them, MR was also carried out. 44 patients had hyperplasia at histology. On CT, thymic hyperplasia was confirmed in 16 cases, thymoma was diagnosed in 10 and a normal thymus in 18 (sensitivity 36%, specificity 95%). Of 52 patients with thymoma at histology, CT showed thymoma in 46, hyperplasia in 1, and normal thymus in 5. CT showed 88.5% sensitivity and 77% specificity for thymoma. In 10 patients with invasive thymoma, CT was indiscriminate, while invasiveness was detected in 7 cases at MR (70% sensitivity) and at CT in 1 case. Both CT and MR detected tumor recurrence in 5 cases, but the exact localization and degree of invasion were best defined by MR.CONCLUSION:
In MG patients CT is a sensitive, specific and efficient modality for detecting thymoma, but is less so for detecting thymic hyperplasia. MR was shown to be accurate in detecting invasive thymoma both preoperatively and in postoperative follow-up.
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Base de dados:
MEDLINE
Assunto principal:
Timo
/
Hiperplasia do Timo
/
Neoplasias do Timo
/
Iohexol
/
Imageamento por Ressonância Magnética
/
Tomografia Computadorizada por Raios X
/
Miastenia Gravis
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article