Lack of reported mutations in a Japanese case of toxic multinodular goiter.
ORL J Otorhinolaryngol Relat Spec
; 64(4): 275-7, 2002.
Article
em En
| MEDLINE
| ID: mdl-12232474
We describe a toxic multinodular goiter that was subjected to genomic sequencing of the thyroid-stimulating hormone receptor and the alpha-subunit of the stimulatory guanine nucleotide-binding protein. No mutation was detected in either gene. While frequent occurrence of thyroid-stimulating hormone receptor gene mutations in toxic multinodular goiters has been reported in areas such as part of Europe with a relatively high prevalence of iodine deficiency, toxic multinodular goiters in areas with an abundance of dietary iodine such as Japan seem unlikely to involve mutations of this gene.
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Base de dados:
MEDLINE
Assunto principal:
Bócio Nodular
/
Hipertireoidismo
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article