Production of lovastatin examined by an integrated approach based on chemometrics and DOSY-NMR.
Biotechnol Bioeng
; 80(5): 589-93, 2002 Dec 05.
Article
em En
| MEDLINE
| ID: mdl-12355470
ABSTRACT
Microbial secondary metabolites are one of the sources of therapeutic molecules in the pharmaceutical industry. Product quality and high yields of secondary metabolites are the main goals for the commercial success of a fermentation process. Our novel approach was based on the decision-tree algorithm to determine the key variables correlated with the process outcome and on DOSY-NMR to identify both co-metabolites and impurities, and it improves fermentation systems and speeds up bioprocess development. The approach has been validated in the case of lovastatin production from Aspergillus terreus.
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Base de dados:
MEDLINE
Assunto principal:
Aspergillus
/
Algoritmos
/
Lovastatina
/
Espectroscopia de Ressonância Magnética
/
Técnicas de Química Combinatória
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article