Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation.
Bioorg Med Chem Lett
; 12(21): 3111-5, 2002 Nov 04.
Article
em En
| MEDLINE
| ID: mdl-12372513
A series of chiral benzylpiperazinyl-1-(2,3-dihydro-indol-1-yl)ethanone derivatives were prepared and examined for their affinity at dopamine D(2) and D(4) receptors. Three compounds having D(2)/D(4) affinity ratios approximating that found for the atypical neuroleptic clozapine were further evaluated in behavioral tests of antipsychotic efficacy and motor side effects.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Antagonistas de Dopamina
/
Antagonistas dos Receptores de Dopamina D2
/
Indóis
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article