Neurotransmitter regulation of neural development: acetylcholine and nicotinic receptors.
An Acad Bras Cienc
; 74(3): 453-61, 2002 Sep.
Article
em En
| MEDLINE
| ID: mdl-12378313
ABSTRACT
Several neurotransmitter systems have been related to developmental processes during the past decade. In this review, we discuss the evidence that the nicotinic acetylcholine receptors could have an additional function during development that may be unrelated to their role in cholinergic neurotransmission in the vertebrate brain. Both temporal expression data and in vitro and in vivo studies with nicotinic agonists and antagonists have provided direct support for a role of nicotinic receptors in neural developmental processes such as neurite outgrowth and differentiation. A similar picture has emerged for other neurotransmitter and receptor systems as well, which generates a new view of neural processes during both development and mature life.
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Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Central
/
Receptores Nicotínicos
/
Sistema Nervoso Periférico
/
Neurotransmissores
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article