Immunolocalization of PTCH protein in odontogenic cysts and tumors.
J Dent Res
; 81(11): 757-60, 2002 Nov.
Article
em En
| MEDLINE
| ID: mdl-12407090
ABSTRACT
The human patched gene (PTCH) functions in both embryologic development and tumor suppression. PTCH mutations have been found in odontogenic keratocysts. However, the expression and localization of the protein product of the gene have not been determined in odontogenic tumors and cysts. We investigated 68 odontogenic lesions by immunohistochemistry, and compared their PTCH expression with that in basal cell carcinomas. All odontogenic lesions, including two keratocysts with truncating mutations, were positive for PTCH. Different types of lesions had different amounts of staining. Lack of staining was noted in the majority of basal cell carcinomas. Taken together, these data suggest that odontogenic keratocysts arise with heterozygous mutations of the PTCH gene.
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Base de dados:
MEDLINE
Assunto principal:
Cistos Odontogênicos
/
Tumores Odontogênicos
/
Proteínas de Membrana
/
Proteínas de Neoplasias
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article