Motors and switches: AAA+ machines within the replisome.
Nat Rev Mol Cell Biol
; 3(11): 826-35, 2002 Nov.
Article
em En
| MEDLINE
| ID: mdl-12415300
ABSTRACT
Clamp loaders are required to load the ring-shaped clamps that tether replicative DNA polymerases onto DNA. Recently solved crystal structures, along with a series of biochemical studies, have provided a detailed understanding of the clamp loading reaction. In particular, studies of the Escherichia coli clamp loader--an AAA+ machine--have provided insights into the architecture of clamp loaders from eukaryotes, bacteriophage T4 and archaea. Other AAA+ proteins are also involved in the initiation of DNA replication, and studies of the E. coli clamp loader indicate mechanisms by which these proteins might function.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Motores Moleculares
/
Proteínas de Ligação a DNA
/
Replicação do DNA
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article