Gating of the expressed Cav3.1 calcium channel.
FEBS Lett
; 531(2): 235-40, 2002 Nov 06.
Article
em En
| MEDLINE
| ID: mdl-12417318
ABSTRACT
Intramembrane charge movement originating from Cav3.1 (T-type) channel expressed in HEK 293 cells was investigated. Ion current was blocked by 1 mM La3+. Charge movement was detectable for depolarizations above approximately -70 mV and saturated above +60 mV. The voltage dependence of charge movement followed a single Boltzmann function with half-maximal activation voltage +12.9 mV and +12.3 mV and with slopes of 22.4 mV and 18.1 mV for the ON- and OFF-charge movement, respectively. Inactivation of I(Ca) by prolonged depolarization pulse did not immobilize intramembrane charge movement in the Cav3.1 channel.
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Base de dados:
MEDLINE
Assunto principal:
Ativação do Canal Iônico
/
Canais de Cálcio Tipo T
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article