Effect of suppressive DNA on CpG-induced immune activation.
J Immunol
; 169(10): 5590-4, 2002 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-12421936
ABSTRACT
Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs stimulate a strong innate immune response. This stimulation can be abrogated by either removing the CpG DNA or adding inhibitory/suppressive motifs. Suppression is dominant over stimulation and is specific for CpG-induced immune responses (having no effect on LPS- or Con A-induced activation). Individual cells noncompetitively internalize both stimulatory and suppressive ODN. Studies using ODN composed of both stimulatory and suppressive motifs indicate that sequence recognition proceeds in a 5'-->3' direction, and that a 5' motif can block recognition of immediately 3' sequences. These findings contribute to our understanding of the immunomodulatory activity of DNA-based products and the rules that govern immune recognition of stimulatory and suppressive motifs.
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Base de dados:
MEDLINE
Assunto principal:
Oligodesoxirribonucleotídeos
/
DNA
/
Ativação Linfocitária
/
Adjuvantes Imunológicos
/
Ilhas de CpG
/
Imunossupressores
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article