Bioactive 4-substituted-6-methyl-2-pyrones with promising cytotoxicity against A2780 and K562 cell lines.
Bioorg Med Chem Lett
; 12(24): 3509-13, 2002 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-12443764
ABSTRACT
Bioactive synthetic 4-substituted-6-methyl-2-pyrones are reported. Various 4-substitutents have been incorporated using Pd-catalysed carbon-carbon bond coupling procedures. Preliminary screening of the 2-pyrones against human ovarian carcinoma (A2780) and human chronic myelogenous leukaemia (K562) cell lines show that 4-alkynyl-6-methyl-2-pyrones have excellent potential as anticancer agents. The pyrones demonstrate broad spectrum antimicrobial activities.
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Base de dados:
MEDLINE
Assunto principal:
Pironas
/
Anti-Infecciosos
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article