Synchronization in a network of fast-spiking interneurons.
Biosystems
; 67(1-3): 45-53, 2002.
Article
em En
| MEDLINE
| ID: mdl-12459283
ABSTRACT
Experimental results revealed that in neocortex inhibitory fast-spiking (FS) interneurons interact also by electrical synapses (gap-junctions). They receive sensory information from thalamus and transfer it to principal cells by feedforward inhibition. Moreover, their synchronous discharge enhances their inhibitory control of pyramidal neurons. By using a biophysical model of FS interneurons the synchronization properties of a network of two synaptically coupled units are investigated. In the case they interact only by inhibitory synapses, well defined regions exist in the parameters space described by the strength and duration of the synaptic current, where synchronous regimes occur. Then an empirical protocol is proposed to determine approximately the borders of the synchronization manifold (SM). When electrical synapses are included, the region of synchronous discharge of the two interneurons becomes larger. In both cases, the coherent states are characterized by discharge frequencies in the gamma range. Lastly, the effects of heterogeneity, either obtained by using different stimulation currents or unidirectional inhibitory coupling, are studied.
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Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
/
Redes Neurais de Computação
/
Sincronização Cortical
/
Interneurônios
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article