Differential diagnosis of kidney transplant rejection and cyclosporin/tacrolimus nephropathy using urine cytology.
Clin Transplant
; 16 Suppl 8: 40-4, 2002.
Article
em En
| MEDLINE
| ID: mdl-12464131
ABSTRACT
A total of 9000 urine samples from 69 kidney transplant recipients were studied for differential diagnoses of transplant rejection and cyclosporin/tacrolimus toxicity. New-Sternheimer and Papanicolaou staining were used to differentiate cells in urine. We also employed an immunocytochemical technique for further identification of exfoliated cells. With New-Sternheimer and Papanicolaou staining, the predominance of proximal tubular cells was useful to differentiate cyclosporin/tacrolimus toxicity from acute rejection in cases of increased serum creatinine level. During rejection episodes, an increased number of mononuclear cells and renal epithelial cells were found. Immunocytochemical analysis showed a significant increase of CD2-, CD4- CD8-, CD25- and HLA-DR-positive cells with rejection. However, there was no relationship between Banff criteria rejection grade and the increase of mononuclear cells.
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
/
Tacrolimo
/
Ciclosporina
/
Rejeição de Enxerto
/
Imunossupressores
/
Nefropatias
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article