Stephacidin A and B: two structurally novel, selective inhibitors of the testosterone-dependent prostate LNCaP cells.
J Am Chem Soc
; 124(49): 14556-7, 2002 Dec 11.
Article
em En
| MEDLINE
| ID: mdl-12465964
ABSTRACT
Two novel antitumor alkaloids, Stephacidin A and B, were isolated from the solid fermentation of Aspergillus ochraceus WC76466. Both alkaloids exhibit in vitro cytotoxicity against a number of human tumor cell lines; however, stephacidin B demonstrated more potent and selective antitumor activities, especially against prostate testeosterone-dependent LNCaP cells with IC50 value of 60 nM. The structures of stephacidin A and B were established on the basis of the NMR data and X-ray crystallography. With 15 rings and 9 chiral centers, stephacidin B represents one of the most structurally complex and novel alkaloids occurring in nature.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Aspergillus ochraceus
/
Indóis
/
Neoplasias Hormônio-Dependentes
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article