Interleukin-12 inhibits apoptosis in chronic lymphatic leukemia (CLL) B cells.
Cancer Biother Radiopharm
; 17(5): 495-9, 2002 Oct.
Article
em En
| MEDLINE
| ID: mdl-12470418
ABSTRACT
The purpose of the present study was to investigate the effect of interleukin-12 on apoptosis of chronic lymphatic leukemia (CLL) B cells. Apoptotic indices were determined in highly purified CD5(+) B lymphocytes isolated from peripheral blood of seven patients with histologically confirmed CLL. Interleukin-4 as a known inhibitor of apoptosis was used as control. Quantitative analysis of apoptosis was determined by cell death detection ELISA. Our findings indicate that interleukin-12 inhibits ex vivo apoptosis in a large proportion of B-CLL patients and may be closely involved in the pathogenesis of disease. Therefore, our results may help identify potential new therapeutic targets in this malignancy.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Linfocítica Crônica de Células B
/
Apoptose
/
Interleucina-12
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article