Hypoglycemic activity of ginseng glycopeptide.
Acta Pharmacol Sin
; 24(1): 50-4, 2003 Jan.
Article
em En
| MEDLINE
| ID: mdl-12511229
ABSTRACT
AIM:
To study the hypoglycemic activity of ginseng glycopeptide (GGP).METHODS:
Normal mice or rabbits and alloxan or streptozotocin-induced hyperglycemic rats or mice were used in the study. Blood glucose and liver glycogen levels of the experimental animals during the trial period were analyzed by spectrophotometry with O-toluidine and iodine reagents, respectively.RESULTS:
Significant decreases in blood glucose and liver glycogen levels were induced in a dose-dependent manner after administration of GGP 50, 100, or 200 mg/kg injected ip or sc to normal mice and injected im 30 or 60 mg/kg to normal rabbits. The hypoglycemic activity of GGP lasted for about 16 h, and were examined in both normal animals and hyperglycemic animals.CONCLUSION:
GGP injection induced the pronounced decreases in blood glucose and liver glycogen levels in both normal and hyperglycemic animals.
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Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Glicopeptídeos
/
Panax
/
Hiperglicemia
/
Hipoglicemiantes
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article