[An experimental study on inhibitory effect of xinjierkang granules on virus myocarditis].

ABSTRACT

OBJECTIVE: To investigate the inhibitory effect of Xinjierkang(XJEK) granules on virus myocarditis. METHODS: Using a model mouse of virus myocarditis induced by coxsackie virus B3m (CVB3m) and mouse toxic myocarditis induced by adriamycin, a model of arrhythmia induced by BaCl2 and CHCl3, a model of inflammation caused by egg white and agar, along with a dynamic test of cardiac blood flow and an inhibitory test of CVB3m in vitro. RESULTS: XJEK granules are efficacious in inhibiting CVB3m both in vitro and in vivo, protecting and curing virus myocarditis and toxic myocarditis in mice, reducing mouse death rate, serum level of LDH, AST and CK, titer of neutralizing antibodies, virus concentration of heart, and improving the abnormal ECG, pathological and ultrastructural damage of myocadium. The granules are also good for anti-inflammation, anti-myocardial ischemia, anti-arrhythmia, as well as for strengthening myocardiac contraction and increasing the serum IgG level. CONCLUSION: Xinjerkang granules possess an inhibitory effect on virus myocarditis and toxic myocarditis.