Effects of acute and chronic caffeine intake on intravenous self-administration of morphine in two rat strains.

Sudakov, S K; Papazov, I P; Lyupina, Yu V; Medvedeva, O F; Figurina, I V; Rusakova, I V

Sudakov, S K; Papazov, I P; Lyupina, Yu V; Medvedeva, O F; Figurina, I V; Rusakova, I V.

Afiliação

Sudakov SK; Institute of Biomedical Engineering, Moscow, Russia. s-sudakov@mtu-net.ru

Bull Exp Biol Med ; 134(4): 400-2, 2002 Oct.

Article em En | MEDLINE | ID: mdl-12533771

ABSTRACT

ABSTRACT

Effects of acute and chronic caffeine intake on the level and pattern of morphine self-administration behavior in WAG/G and Fisher-344 rats were studied. Both acute and chronic caffeine intake decreased morphine self-administration only in WAG/G rats, which attested to increased sensitivity of these rats to reinforcing effects of morphine. Possible relationship between the observed changes and increased anxiety in rats receiving caffeine is discussed.

Assuntos

Cafeína/farmacologia; Morfina/administração & dosagem; Animais; Ansiedade/etiologia; Comportamento Animal; Relação Dose-Resposta a Droga; Comportamento Alimentar; Masculino; Ratos; Ratos Endogâmicos F344; Ratos Endogâmicos; Autoadministração; Especificidade da Espécie; Fatores de Tempo

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