Effects of acute and chronic caffeine intake on intravenous self-administration of morphine in two rat strains.
Bull Exp Biol Med
; 134(4): 400-2, 2002 Oct.
Article
em En
| MEDLINE
| ID: mdl-12533771
ABSTRACT
Effects of acute and chronic caffeine intake on the level and pattern of morphine self-administration behavior in WAG/G and Fisher-344 rats were studied. Both acute and chronic caffeine intake decreased morphine self-administration only in WAG/G rats, which attested to increased sensitivity of these rats to reinforcing effects of morphine. Possible relationship between the observed changes and increased anxiety in rats receiving caffeine is discussed.
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Base de dados:
MEDLINE
Assunto principal:
Cafeína
/
Morfina
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article