Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2.
J Virol
; 77(4): 2757-61, 2003 Feb.
Article
em En
| MEDLINE
| ID: mdl-12552018
ABSTRACT
We have identified an HLA-A2-restricted CD8(+) T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cisteína Endopeptidases
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Herpesvirus Humano 4
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Linfócitos T CD8-Positivos
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Transportadores de Cassetes de Ligação de ATP
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Epitopos de Linfócito T
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article