[Terbium sensitized chemiluminescence of enoxacin].

ABSTRACT

AIM: To determine the enoxacin by means of terbium sensitized chemiluminescence in pharmaceutical preparations as well as urine samples. METHODS: Through six-way injection valve Ce4+, H2SO3, Tb3+ and enoxacin (ENX) standard solutions were injected into the flow system in a certain order, the chemiluminescence signal was detected by weak luminescence analyzer. RESULTS: The chemiluminescence intensity was linearly related to the concentration of ENX in the range of 2.0 x 10(-9)-6.0 x 10(-8) mol.L-1 with a detection limit of 4.0 x 10(-10) mol.L-1. Relative standard deviation was less than 1.6% (n = 11). CONCLUSION: It provides a sensitive rapid, simple and accuracy measurement of enoxacin for the pharmacokinetic studies.