[Genetic polymorphism of the STR DXS9898 locus in Han population].

ABSTRACT

OBJECTIVE: Studying the genetic polymorphism of X-STR locus DXS9898 in Han population. METHODS: 296 unrelated Chinese individuals (199 females and 97 males) living in Chengdu were investigated using PCR and PAG electrophoresis followed by silver staining. RESULTS: 6 alleles were observed and the range of fragment size was 189-214 bp. The genotype distribution of DXS9898 locus was in accordance with Hardy-Weinberg equilibrium. Family survey confirmed Mendelian inheritance of alleles. The observed heterozygosity in females was 0.5930, the discriminating power (Dp) were 0.5667 and 0.9420 for males and females respectively. The power of exclusion were 0.5862 and 0.4392 for trio and duo respectively. CONCLUSION: The results demonstrated that the locus is highly polymorphic and can be used in forensic identification and parentage testing.