N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.
Bioorg Med Chem Lett
; 13(6): 1087-92, 2003 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-12643918
ABSTRACT
A series of sulfamate surrogates of methionyl and isoleucyl adenylate have been investigated as MetRS and IleRS inhibitors by modifications of the sulfamate linker and adenine moieties. The discovery of 2-iodo Ile-NHSO(2)-AMP (58) as a potent Escherichia coli IleRS inhibitor revealed that a significant hydrophobic interaction between the 2-substituent of Ile-NHSO(2)-AMP and the adenine binding site of IleRS provided its high potency to the enzyme.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Ácidos Sulfônicos
/
Inibidores Enzimáticos
/
Isoleucina-tRNA Ligase
/
Metionina tRNA Ligase
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article