Inflammatory myofibroblastic tumor: a spinal case with aggressive clinical course and ALK overexpression. Case report.
J Neurosurg
; 98(2 Suppl): 218-21, 2003 Mar.
Article
em En
| MEDLINE
| ID: mdl-12650409
ABSTRACT
The authors report on a case of spinal inflammatory myofibroblastic tumor (IMT) in a 22-year-oldwoman. Neuroradiological features of this intradural extramedullary mass were suggestive of a meningioma or neurinoma. The lesion was easily resected following a T-9 laminectomy. Light microscopy showed a proliferation of spindle cells with prominent nucleoli on a fibrous or edematous background with infiltration of numerous lymphocytes and plasma cells. Some spindle cells immunostained positively for ALK1. This led to the diagnosis of IMT. The patient's postoperative course was complicated by a multifocal local recurrence requiring a second surgery, which was followed by radio- and chemotherapy. The occurrence of IMT in the spinal cord has rarely been reported. In this case, ALK overexpression was associated with early multifocal recurrence. This has been recently reported in this tumor typein other locations.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Medula Espinal
/
Proteínas Tirosina Quinases
/
Fibroblastos
/
Músculo Liso
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article