Neuropsychological outcome in long-term survivors of a childhood extracranial solid tumor who have undergone autologous bone marrow transplantation.
Bone Marrow Transplant
; 31(7): 599-606, 2003 Apr.
Article
em En
| MEDLINE
| ID: mdl-12692628
ABSTRACT
The purpose of this study was to evaluate neuropsychological and adaptive functioning of children who have undergone bone marrow transplantation (BMT) without previous cranial irradiation. In total, 76 children treated for an extracranial tumor with BMT without total body irradiation (TBI) were evaluated at least 5 years after the end of the treatment.Overall, their performance and skills were in the normal range and their professional and academic outcomes were satisfactory. Nevertheless, we observed a deleterious effect of deafness on verbal IQ associated with the previous administration of cisplatin during conventional chemotherapy. In addition, reading difficulties had arisen. This could be related to absence from kindergarten or primary school during hospitalization. Finally, in the younger subgroup, visual-perceptual skills were found to be more fragile.
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Medula Óssea
/
Neoplasias do Sistema Nervoso
/
Neuroblastoma
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article