Plasma total homocysteine in uncomplicated pregnancy and in preeclampsia.
Eur J Obstet Gynecol Reprod Biol
; 108(1): 45-9, 2003 May 01.
Article
em En
| MEDLINE
| ID: mdl-12694969
ABSTRACT
OBJECTIVES:
(a) To establish the reference values for plasma total homocysteine in our pregnant population. (b) To determine the possible association between hyperhomocysteinemia and preeclampsia in our geographical area. STUDYDESIGN:
Control-case study with 32 preeclamptic patients and 64 controls without pregnancy complications. Plasma total homocysteine, determined by HPLC (fluorescence detection), was correlated with serum folate and Vitamin B(12) (analyzed by competitive protein binding chemiluminescent assay). STATISTICAL ANALYSES Mann-Whitney, Wilcoxon and Spearman test (SPSS, 10.0).RESULTS:
Homocysteine concentrations in the controls were significantly higher while folate was significantly lower in the third trimester of pregnancy when compared with the second (P<0.0001). Homocysteine and folate values were significantly higher in patients compared with controls in the third trimester (P=0.005 and 0.005, respectively). The OR for preeclampsia in hyperhomocysteinemia was 7.7 (95% CI 1.7-34.8).CONCLUSION:
Pregnant women with hyperhomocysteinemia have a 7.7-fold risk for preeclampsia (CI 95% 1.7-34.8) compared with normal controls.
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Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Homocisteína
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article