Prevalence of antibodies to hepatitis A and hepatitis E virus in urban school children in Chennai.

ABSTRACT

With similar feco-oral mode of transmission of Hepatitis A and E viruses, and improving levels of personal hygiene among higher socioeconomic population, periodic surveillance on HAV/HEV exposure pattern may be of immense public health value. One such attempt was made in Tamilnadu, India by analysing the presence of antibodies to HAV and HEV in 185 healthy children of 6 months to 12 years of age. While anti HAV positivity was 96.9% by 12 years of age, anti HEV positivity fluctuated between 5.3-16.7%. The study suggests the necessity for developing a vaccine for HEV to prevent the frequent occurrence of HEV outbreaks in India, since natural HEV exposure does not bestow significant protection as observed in HAV.