Impairment of radial maze delayed nonmatching after lesions of anterior thalamus and parahippocampal cortex.
Behav Neurosci
; 117(3): 596-605, 2003 Jun.
Article
em En
| MEDLINE
| ID: mdl-12802887
ABSTRACT
This study compared the effects of lesions damaging hippocampus-related pathways in anterior thalamus (AT) and parahippocampal (PH) cortex on allocentric spatial memory. Rats were trained to perform radial maze delayed nonmatching (DNM) with random selection of arms to prevent egocentric solutions. After experimental treatment (control, excitotoxic AT, radiofrequency PH, or combined AT-PH lesions), rats were retrained for 30 sessions from 2 to 8 weeks after surgery. Results showed comparable impairments for AT and PH lesions that added without interaction in the combined AT-PH group. During chronic recovery, the AT-PH group exhibited delay-dependent deficits comparable to previous results for hippocampal lesions. Thus, AT and PH lesions appear to have separate effects that together disrupt hippocampus-dependent spatial memory.
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Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Aprendizagem em Labirinto
/
Giro Para-Hipocampal
/
Núcleos Anteriores do Tálamo
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article