IV amantadine improves chorea in Huntington's disease: an acute randomized, controlled study.
Neurology
; 60(12): 1995-7, 2003 Jun 24.
Article
em En
| MEDLINE
| ID: mdl-12821751
ABSTRACT
The acute antidyskinetic effects of IV amantadine in HD were evaluated. A 2-hour IV infusion of amantadine or placebo was administered to nine patients with HD on two different days in a double-blind, randomized crossover fashion. All patients subsequently received oral amantadine unblinded for a 1-year period. A reduction of dyskinesia scores was reported during both IV and oral amantadine treatment (p < 0.05). No significant changes were observed in neuropsychological tests or psychiatric rating scales.
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Base de dados:
MEDLINE
Assunto principal:
Amantadina
/
Doença de Huntington
/
Antagonistas de Aminoácidos Excitatórios
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article