Immunofluorescence studies using skin sections of recessive dystrophic epidermolysis bullosa patients indicated that the antigen of anti-p200 pemphigoid is not a fragment of type VII collagen.
J Dermatol Sci
; 32(2): 125-9, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-12850304
ABSTRACT
BACKGROUND:
There are a large number of autoimmune bullous diseases, which have distinct autoantibodies. Several reports on cases with IgG autoantibodies against a novel 200 kDa dermal protein have been published, for which we suggested the term, anti-p200 pemphigoid. However, the nature of this 200 kDa antigen has not been well characterized.OBJECTIVE:
In this study, we examined the relationship between the 200 kDa protein and type VII collagen.METHODS:
We collected sera from 12 cases of anti-p200 pemphigoid and skin sections from six cases of recessive dystrophic epidermolysis bullosa (RDEB). The reactivity of these sera was examined by indirect immunofluorescence using sections of the disease skin.RESULTS:
we have shown that all the 12 anti-p200 pemphigoid sera could react with basement membrane zone of five cases of RDEB, while epidermolysis bullosa acquisita (EBA) sera were negative in these skins. In addition, in a case of RDEB, EBA sera reacted with intracytoplasmic deposition of type VII collagen, while no anti-p200 pemphigoid sera showed this reactivity.CONCLUSION:
These results strongly suggested that the 200 kDa antigen is not a fragment of type VII collagen, but a specific autoantigen.
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Base de dados:
MEDLINE
Assunto principal:
Pele
/
Autoantígenos
/
Epidermólise Bolhosa Distrófica
/
Colágeno Tipo VII
/
Genes Recessivos
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article