Expression of leukotriene C4 synthase mRNA by the choroid plexus in mouse brain suggests novel neurohormone functions of cysteinyl leukotrienes.
Biochem Biophys Res Commun
; 307(4): 987-90, 2003 Aug 08.
Article
em En
| MEDLINE
| ID: mdl-12878209
ABSTRACT
Leukotriene C(4) is a potent mediator of allergic and inflammatory reactions, and is formed from arachidonic acid and glutathione through the sequential action of 5-lipoxygenase and leukotriene C(4) synthase (LTCS). These enzymes are predominantly expressed in cells of myeloid lineage. In this report, we have investigated LTCS mRNA expression in mouse brain. Expression was demonstrated using RT-PCR and RNase protection assays. In situ hybridization experiments showed exclusive staining of the choroid plexus of all brain ventricles. This expression pattern may provide a mechanism for the generation of LTC(4) on the cerebral side of the blood-brain barrier and suggests a possible novel regulator function of LTC(4) in the formation of cerebrospinal fluid.
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Base de dados:
MEDLINE
Assunto principal:
Plexo Corióideo
/
Glutationa Transferase
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article