Reciprocal serotonergic connections between the hamster median and dorsal raphe nuclei.
Brain Res
; 981(1-2): 126-32, 2003 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-12885433
ABSTRACT
The median (MnR), but not the dorsal (DR) raphe, sends a serotonergic projection to the suprachiasmatic (SCN) nucleus. Stimulation of either nucleus by electrode or serotonin agonist yields equivalent effects on circadian rhythmicity. This and other evidence suggests the existence of a functional serotonergic pathway from the DR to the MnR that may participate in circadian rhythm regulation. The present investigation was designed to identify such a connection. Tract tracer studies revealed cells in the DR that project to the MnR, as well as cells in the MnR that project to the DR. Double label immunofluorescence methods demonstrated that some of the cells projecting from either nucleus to the other contain serotonin immunoreactivity. The results support the existence of a reciprocal pathway between the DR and MnR that is at least partially serotonergic.
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Base de dados:
MEDLINE
Assunto principal:
Núcleos da Rafe
/
Serotonina
/
Vias Neurais
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article