[Alveolar hemorrhage as a possible adverse drug reaction by gefitinib (ZD1839, Iressa)].
Gan To Kagaku Ryoho
; 30(7): 977-80, 2003 Jul.
Article
em Ja
| MEDLINE
| ID: mdl-12894713
ABSTRACT
We experienced a case in which severe alveolar hemorrhage occurred in the course of gefitinib therapy. A 56-year-old man with non-small cell lung cancer had been treated with CDDP + CPT-11, CDDP + GEM + VNR, CDDP + TXT. After the chemotherapy with these regimens was found to be ineffective, daily oral gefitinib was started. Four weeks later, the patient complained of cough, bloody sputum and dyspnea. Chest X-ray and CT showed bilateral infiltrations with air bronchogram. Fiberoptic bronchoscopy revealed alveolar hemorrhage with an increase of lymphocytes in the BALF. After the cessation of gefitinib therapy and the administration of steroid, he gradually recovered.
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Base de dados:
MEDLINE
Assunto principal:
Quinazolinas
/
Adenocarcinoma
/
Hemorragia
/
Pneumopatias
/
Neoplasias Pulmonares
/
Antineoplásicos
Idioma:
Ja
Ano de publicação:
2003
Tipo de documento:
Article