The Ovo/Shavenbaby transcription factor specifies actin remodelling during epidermal differentiation in Drosophila.
Mech Dev
; 120(7): 747-58, 2003 Jul.
Article
em En
| MEDLINE
| ID: mdl-12915226
ABSTRACT
In Drosophila, differentiation of the epidermis results in a stereotyped array of cells with F-actin-based extensions at their apical face. We identified Ovo/Shavenbaby (Svb) as a transcription factor that governs changes in epidermal cell shape. Svb is required for the formation of apical extensions and cells deficient in svb differentiate a smooth surface. In both the embryo and the adult, we show that Svb is necessary and sufficient for the cells to grow extensions and that the tight regulation of ovo/svb activity is critical for morphogenesis to occur correctly. We establish that Svb triggers early F-actin redistribution and is able to initiate the entire process of cytoskeletal remodelling, thereby defining it as a major regulator of epidermal differentiation.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Diferenciação Celular
/
Actinas
/
Proteínas de Drosophila
/
Proteínas de Ligação a DNA
/
Epiderme
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article