Effects of Ser130Gly and Asp240Lys substitutions in extended-spectrum beta-lactamase CTX-M-9.
Antimicrob Agents Chemother
; 47(9): 2958-61, 2003 Sep.
Article
em En
| MEDLINE
| ID: mdl-12937001
ABSTRACT
In CTX-M-9 extended-spectrum beta-lactamases (ESBLs), an S130G mutation induced a 40- to 650-fold increase in 50% inhibitory concentrations but decreased hydrolytic activity against cefotaxime. A D240K mutation did not modify enzymatic efficiency against ceftazidime. Residue K240 could interact with Q270 and therefore not with ceftazidime, in contrast with what was observed with certain TEM/SHV-type ESBLs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Beta-Lactamases
/
Proteínas de Escherichia coli
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article