Evaluation of topical anti-inflammatory steroid formulations in an Arthus model of inflammation.
J Invest Dermatol
; 66(3): 157-60, 1976 Mar.
Article
em En
| MEDLINE
| ID: mdl-129493
ABSTRACT
Formulations of a number of steroids were evaluated after topical application in a reversed passive Arthus test (RPA) in rabbits. Four 21-chlorosteroids in the same cream base were investigated. The preparations of SQ 18,566 (halcinonide) and SQ 20,811 showed anti-edema activity, but those of SQ 15,361 and SQ 20,589 were less active. Ointment formulations of halcinonide also reduced edema in the RPA. These results, coupled with previously reported clinical data, suggest that the RPA might be utilized to distinguish good from poor formulations of anti-inflammatory steroids prior to screening tests or clinical trials in humans.
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Base de dados:
MEDLINE
Assunto principal:
Reação de Arthus
/
Inflamação
/
Anti-Inflamatórios
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article